Facilities and available techniques
NanoBioMat relies on a combination of in-house experimental capabilities and associated research platforms for the synthesis, formulation, characterization and biological evaluation of magnetic nanoassemblies.
Nanoparticle synthesis and formulation
Magnetic nanoparticle synthesis
- Iron oxide nanoparticle synthesis
- Control of size, morphology and surface chemistry
- Preparation of hydrophobic and water-dispersible nanoparticles
Nanoassembly formulation
- Flash nanoprecipitation
- Confined impinging jets mixing
- Polymer coating and colloidal stabilization
- Hybrid magnetic nanoassemblies incorporating hydrophobic active molecules
Physicochemical characterization
- Dynamic light scattering and colloidal stability studies
- Zeta potential measurements
- UV-visible and fluorescence spectroscopy
- Fourier-transform infrared spectroscopy
- Iron quantification by atomic absorption spectroscopy
- Thermogravimetric analysis
- Powder X-ray diffraction
Magnetic and magnetothermal characterization
- Magnetic hyperthermia measurements
- Alternating magnetic field exposure
- SAR and ILP determination
- Evaluation of magnetically induced heating in colloidal suspensions
Microscopy and biological evaluation
- Electron microscopy through local and collaborative platforms
- Nanoparticle morphology and nanoassembly imaging
- Cellular uptake studies
- In vitro evaluation on hepatic and immune cell models
- Collaborative access to advanced biological and preclinical models
Associated platforms
Additional characterization and biological studies are performed through CEISAM, Nantes Université and CNRS platforms, as well as through national and international collaborations.