The MAGNETIMA project has been funded by the French National Research Agency through the 2026 call for proposals. The project aims to develop magnetically responsive nanoassemblies for the treatment of immune-mediated liver diseases, with a particular focus on autoimmune hepatitis.

The proposed nanoassemblies combine magnetic iron oxide nanoparticles, an anti-inflammatory drug, a polymer matrix and tolerogenic peptide functionalization. The objective is to explore magnetically activated therapeutic strategies that couple nanomedicine, magnetic stimulation and immune modulation.

The project brings together complementary expertise in magnetic nanoassemblies, magnetic nanomedicine, immunology, liver biology, 3D hepatic models and preclinical imaging. It involves collaborations with CEISAM, the NABI team at Université Paris Cité, CR2TI in Nantes, IRSET in Rennes and the CYCERON imaging platform in Caen.

Coordinator: Lénaïc Lartigue
Host laboratory: CEISAM UMR 6230, Nantes Université / CNRS
Funding: ANR — French National Research Agency

Léa Ponroy gave an excellent oral presentation at the PHOTONANO26 congress in Paris, presenting her work on magnetic/photosensitizer nanoassemblies for combined photodynamic and photothermal therapies.

PHOTONANO26 congress website

Marie-Léa Lalanne gave an excellent oral presentation during the Women & Science – SHE meeting organized at the University of Angers. She presented her PhD work on magnetic hyperthermia and magnetic nanoparticles for biomedical applications.

Women & Science – SHE meeting website

The French patent “Nano-assemblages à base de curcumine ou de dérivé de la curcumine et leur procédé de préparation” was granted in May 2025 by the French National Institute of Industrial Property.

This patent protects magnetic nanoassemblies based on magnetic nanoparticles, curcumin or curcumin derivatives, and stabilizing polymers, prepared by flash nanoprecipitation.

Patent number: FR 3 135 617 B1